Close your left eye and stare at the cross mark in the diagram with your right eye. Off to the right you should be able to see the spot. Don't LOOK at it; just notice that it is there off to the right (if its not, move farther away from the computer screen; you should be able to see the dot if you're a couple of feet away). Now slowly move toward the computer screen. Keep looking at the cross mark while you move. At a particular distance (probably a foot or so), the spot will disappear (it will reappear again if you move even closer). The spot disappears because it falls on the optic nerve head, the hole in the photoreceptor sheet.
So, as you can see, you have a pretty big blind spot, at least as big as the spot in the diagram. What's particularly interesting though is that you don't SEE it. When the spot disappears you still don't SEE a hole. What you see instead is a continuous white field (remember not to LOOK at it; if you do you'll see the spot instead). What you see is something the brain is making up, since the eye isn't actually telling the brain anything at all about that particular part of the picture.